Effect of Plant Seeds Peganum harmala Evaporation on Fertility of White Rats Male Treated with Drug Chlorpromazine
Rafidain Journal of Science,
2014, Volume 25, Issue 4, Pages 1-12
AbstractThe present study includes the investigation of the effect of evaporation with Peganum harmala seeds on hormone FSH, LH, testosterone concentrations and sperm count in male albino rats Rattus norvegicus treated with Chlorpromazine. The rats were aged (3-4) months and weighing (200-300) grams. The first group was a negative control of 10 rats which gavaged with distilled water and the 50 remaining rats gavaged with Chlorpromazine ( 2 mg / kg body weight ) daily for six weeks. The treated animals were divided into 4 groups, each group consists of 10 rats. The positive control was treated with drug only, the second group was evaporated daily for a period of 7 days, the third was evaporated daily for a period of 14 days, the fourth group was evaporated daily for a period of 21 days and the fifth group released for 30 days without treatment .
The results showed a significant decrease in LH, FSH, testosterone hormones concentration and sperm count in a group treated with drug chlorpromazine (control group positive) compared to the negative control group. Also the results demonstrate that evaporation rats with Peganum harmala seeds for 7, 14 and 21 days lead to a significant increase in LH, FSH, testosterone hormones concentration and sperm count as compared with positive groups, while hormones concentration and sperm count did not recover to the normal level in the group which was released for 30 days without treatment.
From this research, it is concluded that evaporation with Peganum harmala seeds causes rearranging the sexual activity in the rats treated with Chlorpromazine.
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