Development of Spectrophotometric Method for the Determination of Metoclopramide. HCl in a Pharmaceutical Preparations
Rafidain Journal of Science,
2014, Volume 25, Issue 3, Pages 10-21
AbstractThis paper includes a development of spectrophotometric method for the determination of metoclopramide.HCl. The method involves the diazotization of metoclopramide.HCl and coupling with pyridoxine. HCl, to form an intense orange colored, water-soluble and stable azo-dye which shows a maximum absorption at 470 nm. Beer's law is obeyed over the range 0.5-30 µg/ml metaclopramide. HCl with a molar absorptivity of 1.98*104 L.mol-1.cm-1, The average recovery is 99.27% and relative standard deviation of 0.124 to 0.778%. This method has been applied successfully to the determination of metoclopramide.HCl in pharmaceutical preparations.
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