The study was conducted to determine the histopathological alternation induced by Cyclophosphamide in brain tissue of albino Mice Mus musculus, tow experiments were carried out, 76 mice were used in the first experiment and 40 mice were used in the second experiments. The concentrations 75,150,225 mg/kg were applied for 1-6 weeks. Current study has been done to demonstrate the histopathological effects causes by Cyclophosphamide on the brain
tissue of albino mice Mus musculus for this, two experiments were carried out, various doses were applied for 1,2,3,4,5 and 6 weeks.
The 1 st experiments included the following concentrations 75,150,225 mg/kg then after, histological examination of the dissected animals revealed on infiltration of monocytes. These were accumulated around the blood vessels. Besides microglial cells appeared in the blood vessels. The latter was centrally located in choroids plexus. Moreover, there was vacculation of astrocytes and nerve cells for the latter, various enlargements were revealed in the cortex neurons cerebellum.
The three Concentrations above were applied the second experimentsfor six successive days. Then after the animals were dissected 7,10 and 14 day after the treatment histological views revealed vacculation of nerve fibers and neurons cells. This was seen in the white matter, Also, conjession of blood vessels was elucidated in the choroids plexus. Moreover, there was increase in the size and number of microglial cells. Respectively. This was mainly observed at the outer surface, accompanied by thickeningof purkenji layer as well as vaculation in the brain was seen.
It is obvious that the pathological effects were correlated with the dose of drug and action of dosing as well as with the duration of exposure to the drug.