In the present investigation, some new 1,3,4-oxadiazole derivatives have been prepared starting from readily available thymol. The reaction of thymol with ethylbromoacetate afforded the ethyl ester (1). Treatment of the latter with hydrazine hydrate yielded the corresponding hydrazide (2).
2,5-Disubstituted-1,3,4- oxadiazole (3a-h) were obtained by the reaction of the hydrazide with substituted benzoic acid in the presence of phosphorous oxychloride.
The structure of the new synthesized compounds were confirmed by spectral and physical means.