Abstract
Standard wounds were made in the backs of 20 rabbits, four groups were divided every group contain five animals which were then treated for 7 days as follows: First: sterile wounds without treatment ; Second: infected wounds with no treatment ; Third: infected wounds dressing with honey; and, Fourth: infected wounds treated with 3% hydrogen peroxide (H2O2). Wounds were infected by inoculating Staphylococcus aureus . All treated wounds showed reduction of inflammatory exudation, faster wound contraction, granulation tissue formation and epithelization. However, the overall healing was significantly higher in wounds treated with honey as compared to H2O2 treated wounds. Honey treated wounds, showed less neutrophilic infiltration and marked proliferation of angioblasts and fibroblasts in comparison to H2O2 treated wounds. Moreover, infected wounds became sterile within one week of application of honey