Abstract
alkaline phosphatase (ALP) and albumin was studied on twenty seven rachitic children aged 6-60 months who attended the outpatient department in Al-Khansa maternity and children's Hospital in Mosul during the period from July 2000 to April 2001 and were followed up 6-8 weeks after treatment by oral massive single dose of vitamin D . The radiological and biochemical characteristics of cases ware ascertained before and after therapy .The biochemical changes ware analyzed by student (t) test.
There was a significant increase in the level of serum calcium(p<0.006), phosphorus, and albumin (P<0.0001), with a significant decrease in the ALP activity after vitamin D therapy with no risk of hypercalcaemia (P< 0.0001).
In conclusion, ALP is the main test in the follow up of rachitic children ,also oral massive single dose of vitamin D is effective in reversal of BBP to normal levels with no risk of hypercalcaemia
Key words: Rickets, Calcium, Phosphorus, Albumin, Alkaline phosphatase, Biochemical Bone Profile, Vitamin D.