Synthesis and Cyclization of some N-(2-Pyridyl) Anthranilic Acids
Rafidain Journal of Science,
2010, Volume 21, Issue 8, Pages 19-29
AbstractA series of N-(2-Pyridyl) anthranilic acids (Ia-f) have been synthesized by Ullmann reaction. Cyclization of (Ib,d,f) by phosphorusoxy chloride (POCl3) gives substituted 5-chlorobenzo [b][1,8] naphthyridine compounds. The reaction progress was followed by thin layer chromatography (TLC), rate flow (Rf) values was recorded, spectral data (IR) and (U.V) were recorded. Elemental analysis (CHNS) and gas chromatography-mass spectrometery (GC/MS) were carried out for some of the synthesized compounds.
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