Synthesis and Study some new Schiff Bases Derived from Pyrazolo-Coumarin
Rafidain Journal of Science,
2021, Volume 30, Issue 1, Pages 78-90
AbstractThe research included the preparation and spectroscopic study of some of Schiff's bases derived from pyrazolo-coumarin by using 3-acetylcumarin (1) as a starting material, which was prepared by condensing a Knoevenagel of the salicylaldehyde derivative with an aceto-methyl acetate compound and using pyridine as a catalyst. (3-Methyl 1-Substituted Pyrazolo[4,5-c] Coumarin) (2a, 2b, 3a, 3b) were synthesized through the reaction of compound (1) with aqueous hydrazine in a basic medium. When the (2a, 2b, 3a, 3b) compounds reacted with an increase of aqueous hydrazine using pyridine as the base medium the (3-Methyl 1-Substituted Pyrazolo]4,5-c[1-Amino Quinoline-2-one) was prepared (4a, 4b, 5a, 5b) by replacing the oxygen atom with a nitrogen atom to create the pyridine ring, In this paper, some Schiff bases are also prepared by reacting (4a, 4b, 5a, 5b) compounds that contain free amino groups with Benzaldehyde or its derivatives to give Schiff base (Substituted Benzylidene (3-Methyl 1-Hydro/ Phenyl/ Amido/ Thiamido Pyrazolo[4,5-c])1-Amino Quinoline-2-one) (6a-e) - (9a-e). The compounds prepared in the research were diagnosed and investigated using physical and spectroscopic methods using the infrared (I.R) spectrum as well as the proton nuclear magnetic resonance (1H-NMR) spectrum.
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