College of Science/ University of Mosul
  • Register
  • Login
  • العربیة

Rafidain Journal of Science

Notice

As part of Open Journals’ initiatives, we create website for scholarly open access journals. If you are responsible for this journal and would like to know more about how to use the editorial system, please visit our website at https://ejournalplus.com or
send us an email to info@ejournalplus.com

We will contact you soon

  1. Home
  2. Volume 28, Issue 2
  3. Author

Current Issue

By Issue

By Subject

Keyword Index

Author Index

Indexing Databases XML

About Journal

Aims and Scope

Editorial Board

Facts and Figures

Publication Ethics

Indexing and Abstracting

Peer Review Process

News

Digital Archiving

Open Access Statement

Authorship

Appeals and complaints

Creative Commons Licence

Journal Funding Sources

Plagiarism Policy

Allegations of Misconduct

Copy Right Policies

Spectrophotometric Determination of Paracetamol Using Diazotization Coupling Reaction

    Enas S. Thanoon

Rafidain Journal of Science, 2019, Volume 28, Issue 2, Pages 76-83
10.33899/rjs.2019.159979

  • Show Article
  • Download
  • Cite
  • Statistics
  • Share

Abstract

An accurate, simple, and sensitive indirect spectrophotometric method which proposed and developed for the determination of paracetamol in different pharmaceutical preparations. The proposed method was based on acid hydrolysis of PAR to produced p-aminophenol (PAP), PAP was diazotization with nitrite ion to form the corresponding diazonium salt, followed by coupling with histidine reagent in alkaline medium to produced azo dye that showed maximum absorbance at 430 nm. Beer's law was obeyed in the concentration rage of 10-500 µg/20 ml (i.e. 0.5-25 ppm). The molar absorpitivity and Sandell's sensitivity of the dye were. 1.118×104 l.mol-1.cm-1and 0.0135 µg.cm-2 respectively. The method successfully has been applied for the determination of PAR in pure form,and its pharmaceutical preparations (tablets, syrup and injection).

).
Keywords:
    paracetamol Indirect Spectrophotometric histidine aminophenol
  • PDF (169 K)
  • XML
(2019). Spectrophotometric Determination of Paracetamol Using Diazotization Coupling Reaction. Rafidain Journal of Science, 28(2), 76-83. doi: 10.33899/rjs.2019.159979
Enas S. Thanoon. "Spectrophotometric Determination of Paracetamol Using Diazotization Coupling Reaction". Rafidain Journal of Science, 28, 2, 2019, 76-83. doi: 10.33899/rjs.2019.159979
(2019). 'Spectrophotometric Determination of Paracetamol Using Diazotization Coupling Reaction', Rafidain Journal of Science, 28(2), pp. 76-83. doi: 10.33899/rjs.2019.159979
Spectrophotometric Determination of Paracetamol Using Diazotization Coupling Reaction. Rafidain Journal of Science, 2019; 28(2): 76-83. doi: 10.33899/rjs.2019.159979
  • RIS
  • EndNote
  • BibTeX
  • APA
  • MLA
  • Harvard
  • Vancouver
  • Article View: 945
  • PDF Download: 3,594
  • LinkedIn
  • Twitter
  • Facebook
  • Google
  • Telegram
  • Home
  • Glossary
  • News
  • Aims and Scope
  • Privacy Policy
  • Sitemap
This journal is licensed under a Creative Commons Attribution 4.0 International (CC-BY 4.0)

Powered by eJournalPlus