Electrochemical Biosensor Hemoglobin Immobilization Determination of the Breast Cancer Drug (Adriamycin)
Rafidain Journal of Science,
Volume 28, Issue 2, Pages 152-163
AbstractElectrochemical biosensor is an effective tool for pharmaceutical analysis due to its simplicity, specificity, sensitivity, fast, cost effective and repetitive measurements with miniaturized and portable devices. The paper illustrates the detail methodology for development of an electrochemical biosensor based on hemoglobin (Hb) film modified for anticancer drug adriamycin (ADM). Square wave voltammetry (SWV) studies of the electrodes before and after immobilizing of HB shows the successful formation of a selectivity of the electrode. The proposed Hb based biosensor allows quantitation over the range 1 to 8010-8M, The suggested biosensor method can be successfully applied to the detection and determination of anticancer drug adriamycin in different drug formulations and can be suggested as a suitable sensor for analysis of Adriamycin in biological samples.ً.
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