Biochemical Studies on Synovial Fluid and Serum from Rheumatoid Arthritis Patients
Rafidain Journal of Science,
2018, Volume 27, Issue 3, Pages 37-46
AbstractThe research included biochemical studies on synovial fluid (SF) samples collected from (48) RA patients. Moreover, blood samples from (158) RA patients and (196) healthy as control were collected.
These patients were divided according to disease activity score-28 (DAS-28) into two groups which comprise severe and moderate.
Physical and chemical analysis of SF revealed of the presence of more than 1 ml, yellow green to gray color, cloudy to opaque, low viscosity, with large fat droplets, bloody fluid, low pH degree, low glucose level, high total protein and albumin levels.
The results revealed that all RA patients had a positive rheumatoid factor (RF+) and the concentration of C- reactive protein (CRP) was found to be (36.73 ± 14.397 and 54.27 ± 17.856) mg/l in serum and SF respectively. Also, the level of Erythrocyte Sedimentation Rate (ESR) was found to be (54.85 ± 22.903) mm/hr.
Additionally, there were low significant levels of hyaluronidase (Hylase) activity in SF when compared with the serum of RA patients. Also, there was a highly significant increase in levels of Hylase, alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) in the serum of RA patients when compared with the serum of healthy control.
Moreover, there were highly significant levels of CRP, ESR, Hylase, ALP and LDH in the serum of RA patients with severe when compared with a moderate. Also there were highly significant levels of CRP, ESR and ALP in the SF of RA patients with severe when compared with a moderate
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