Histopathological and Biochemical Effects of Doxorubicin Drug on the Functions of Heart in White Rats
Rafidain Journal of Science,
2017, Volume 26, Issue 2, Pages 34-43
AbstractThe aim of this study is to know the effect of doxorubicin on the function of heart. The drug was administrated for three and six weeks. The animals were sacrified after 48 hr. of the last inject.
This study revealed a significant increases in the activity of lactate dehydrogenase and Creatine Kinase enzyme in the rats' serum when administrated the animal doxorubicin intraperit oneally, for 3 weeks and not significantly increase when administrated for six weeks. Histopathological changes in cardiac tissues revealed a congestion in the blood vessels thrombus and thickness of the wall blood vessels, a dilation of the blood vessels, a prevascular infilteration of the inflammatory cells, infilteration of the inflammatory cells in cardiac muscle, focal lymphocyte infiltration, oedema, hyalinization and loss of striation.
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