Keywords : paracetamol

The Protective Effect of Ficus Carica Leaves Extract on some Fertility Parameters in Male White Rats (Rattus norvegicus) Treated with Paracetamol Drug

Noori Taha Khalaf; Waad S. Shaher

Rafidain Journal of Science, 2021, Volume 30, Issue 1, Pages 11-20
DOI: 10.33899/rjs.2021.167682

This study was conducted to investigate the protective effect of leaves extract of Ficus carica on some fertility parameters in white rats Rattus norvegicus.
 In this study used (40) male rats (2.5-3) month, weights ranged (200-250) g were divided into (4) groups (10) rat/group. The first group (control group), the second group (paracetamol group), the third group (extract group), the fourth group (extract + paracetamol group). All treatments were given doses every other day for (6) weeks.
 Results showed a significant decreased (P<0.05) in testosterone levels in paracetamol group after the third and sixth weeks of treatment as a compare with control group. While the testosterone level for extract group don’t changed after the third week, but the hormone level increased after sixth week of treatment to exceed the hormone level of the control group. While the (extract + paracetamol) group showed a decrease in testosterone level after the third week, then the hormone level increased to close level of (extract group) after the sixth week of treatment.
 The result revealed a significant decrease in the total sperms count and the percentage of the living sperms at (P<0.05) and increased the percentage of dead and abnormalities sperms of the paracetamol group as a compare with control group, the results showed no significant changes in the total sperms count (P<0.05) of the (extract + paracetamol) group, whereas found a significant change in percentage of living and dead sperms, there were no significant change in abnormalities sperms between the extract group and (extract + paracetamol) group.

Spectrophotometric Determination of Paracetamol Using Diazotization Coupling Reaction

Enas S. Thanoon

Rafidain Journal of Science, 2019, Volume 28, Issue 2, Pages 76-83
DOI: 10.33899/rjs.2019.159979

An accurate, simple, and sensitive indirect spectrophotometric method which proposed and developed for the determination of paracetamol in different pharmaceutical preparations. The proposed method was based on acid hydrolysis of PAR to produced p-aminophenol (PAP), PAP was diazotization with nitrite ion to form the corresponding diazonium salt, followed by coupling with histidine reagent in alkaline medium to produced azo dye that showed maximum absorbance at 430 nm. Beer's law was obeyed in the concentration rage of 10-500 µg/20 ml (i.e. 0.5-25 ppm). The molar absorpitivity and Sandell's sensitivity of the dye were. 1.118×104 0.0135 µ respectively. The method successfully has been applied for the determination of PAR in pure form,and its pharmaceutical preparations (tablets, syrup and injection).


Effects of Paracetamol in Non-Specific Immunological Parameters

Rojan G.M. AL-Allaff

Rafidain Journal of Science, 2018, Volume 27, Issue 4, Pages 223-231
DOI: 10.33899/rjs.2018.159324

Our study includes follow up the effect of excessive dose of paracetamol in some individuals on non- specific immunological parameters, the study estimates total white blood cell count and calculates the absolute number of neutrophils, lymphocytes and monocytes in blood, and estimation of the effectiveness of phagocytic cells of neutrophils. The study included the collection of (30) blood samples from individuals used paracetamol with excessive dose with age range between (20-40) years of both sexes, blood samples individuals donors do not use paracetamol as control samples were used as well. The results showed no significant differences in number of total white blood cell count and number of lymphocytes for individuals with excessive dose of paracetamol compared with control, on another hand the results showed a significant increase in number of neutrophils and monocytes compared with control, concerning the phagocytic activity, the results showed a significant reduction in phagocytic activity in individuals with excessive dose of paracetamol compared with control.

Determination of Paracetamol and Tramadol Hydrochloride in Pharmaceutical Preparations Using Green UV Method

Hana Sh. Mahmood; Nagham T. Dawood

Rafidain Journal of Science, 2018, Volume 27, Issue 1, Pages 36-42
DOI: 10.33899/rjs.2018.141184

A simple, precise, and friendly environmental method for the determination of paracetamol and tramadol hydrochloride in pharmaceutical preparations has been worked out. The method is based on the determination of paracetamol at 242 nm and replaces its concentration in a multicomponent system equation for determination of both paracetamol and tramadol at 227 nm. Beer's law for paracetamol was obeyed over the concentration range 8-25 ppm at 242 nm and 4-16 ppm at 227 nm ,for tramadol it is obeyed over the range 2-14 ppm at 227 nm, water is used as a solvent for dissolution. The method is applicable to the determination of paracetamol and tramadol in their pharmaceutical preparations without prior separation steps from excipients as well as for determination of paracetamol in the presence of tramadol. The average recoveries for determination of mentioned drugs were 94.20-100.14%, and the average relative standard deviation of the method was better than ± 0.646%.