Keywords : Polyphenols


The Effects of Polyphenol Extract of Sumac (Rhus coriaria) Fruits on Body Weights, Lipid Profile and Leptin Hormon Levels in Experimental Mice

Noor F. Al-Hamdany; Khawola A. Al-Flayeh

Rafidain Journal of Science, 2019, Volume 28, Issue 4, Pages 61-75
DOI: 10.33899/rjs.2019.163302

This study included extraction of polyphenol compounds from sumac (Rhus coriaria) fruits that included use of Soxhlet apparatus and 70% ethanol. Also in this study, four groups of experimental mice I-IV, each group of 12 mice were used. Groups II, III, IV were treated orally with polyphenol extract of Sumac fruits of concentration 200, 300, 400 µg /10 g of body weight for periods of two and four weeks. group I was the control (untreated) group. Twelve specimens of blood sera were taken from each of the four groups for the further studies.
The study showed that polyphenol extract exhibited a significant increase (P≤0.05) in the mean values of weights and body mass index in three treated groups of mice II, III, IV for both periods of 2 and 4 weeks respectively, as compared with that of control group I, as well as compared with that of the same groups before treatment with the polyphenol extract of sumac administration.
This study also indicated a significant increase (P≤0.05) in the mean values of following biochemical parameters: glucose, total cholesterol and High Density Lipoprotein-cholesterol    (HDL-c) and a significant decrease (P≤0.05) in Triglyceride (TG) and Very Low Density Lipoprotein-cholesterol (VLDL-c) in blood sera of the three mice groups which were treated with polyphenol extract of sumac as compared with that of control group.
The study on the effects of polyphenol extract on the mean levels of leptin hormon in serum of the three treated experimental of II, III, IV mice for a periods of four weeks were shown a significant increase (P≤0.05) as compared with that of control group. In the mean time the statistical analysis for the correlation coefficient between the mean levels of leptin hormon and the mean values of body weights as well as the mean value of body mass indexe for the treated mice were found to be highly positive +0.65 and +0.58 respectively.
The increased values of leptin hormone levels accompanied by the increase values of mean of body weights and body mass indexes of the treated experimental mice  which were encountered in this study was discussed here in  the view of leptin  working mechanism.